Asymptomatic Myeloma Prognosis Calculator
Predicts risk group for progression of asymptomatic / smoldering multiple myeloma to active multiple myeloma or AL amyloidosis using the older Mayo-Kyle two-variable model.
Use the average percentage from bone marrow aspirate and core biopsy, when available.
Use serum protein electrophoresis value in g/dL.
Risk factor count:
Interpretation:
Median time to progression:
Clinical caution: This calculator is for educational use only.
It should be applied only after confirming smoldering/asymptomatic myeloma and excluding
active myeloma-defining events, CRAB features, and AL amyloidosis. It does not replace
clinician judgment or modern IMWG risk stratification such as the 20/2/20 model.
References:
- Kyle RA et al. Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N Engl J Med. 2007;356:2582-2590.
- Madhira BR et al. Recent Advances in the Management of Smoldering Multiple Myeloma. World J Oncol. 2020;11(2):45-54.
- International Myeloma Working Group diagnostic criteria for multiple myeloma and smoldering multiple myeloma.
