Shapiro Rule Blood Culture Calculator
For adult emergency department patients with suspected infection. Determines whether the clinician should consider obtaining blood cultures based on Shapiro major and minor criteria.
Clinical safety note: This tool is for education and decision support only. It does not replace clinician judgment, local sepsis guidance, antimicrobial stewardship policy, or urgent management of an unstable patient.
- Shapiro NI, Wolfe RE, Wright SB, Moore R, Bates DW. Who needs a blood culture? A prospectively derived and validated prediction rule. Journal of Emergency Medicine. 2008;35(3):255–264.
- Jessen MK et al. Prediction of bacteremia in the emergency department: an external validation of a clinical decision rule. European Journal of Emergency Medicine. 2016;23(1):44–49.
- MDCalc. Shapiro Rule calculator. Used here only as a publicly available reference for criterion structure and educational implementation.

