SAFE Score Calculator
Steatosis-Associated Fibrosis Estimator (SAFE) score calculator for estimating the risk of moderate to advanced liver fibrosis (stage F2 or higher) in patients with MASLD. Higher scores indicate greater fibrosis risk.
The SAFE Score Calculator is a tool that estimates the chance that a person with MASLD has moderate to advanced liver fibrosis, usually defined as stage F2 or higher. It is meant for noninvasive risk stratification, especially in primary care or early evaluation, using routine clinical and lab data rather than biopsy.
The SAFE score uses these inputs:
age, BMI, diabetes status, AST, ALT, globulin, and platelet count. It combines them into a numeric score, where higher scores mean higher fibrosis risk.
The usual interpretation is:
- SAFE < 0: low risk
- SAFE 0 to <100: intermediate or indeterminate risk
- SAFE ≥ 100: high risk
So, in simple terms, a SAFE Score Calculator is a way to screen for clinically important liver fibrosis without an invasive test. It does not diagnose fibrosis by itself, but it helps identify who is lower risk and who may need additional assessment such as elastography or specialist review
