Cisplatin-Associated Acute Kidney Injury Risk Calculator

CP-AKI Risk Calculator

Clinical risk assessment

Cisplatin-Associated Acute Kidney Injury (CP-AKI) Risk Calculator

Estimates the risk category for severe acute kidney injury after a first intravenous cisplatin treatment using the published simplified CP-AKI point score.

Enter the most recent laboratory values obtained before cisplatin. This simplified score adds smoking history and does not assign points for serum creatinine or platelet count; both requested values are retained for clinical context.

Patient information

Validated for adults aged 18 years and older.

Total planned dose for the treatment occasion.

History of hypertension
History of diabetes mellitus
Current or former smoker

Required by the published simplified score.

Recorded for context; no points in the simplified score.

Recorded for context; no points in the simplified score.

Result

Simplified CP-AKI score

0

out of 22.5 points

Risk category

Observed rate in the external validation cohort, not an individual deterministic probability.

Interpretation

Score breakdown

VariablePatient valuePoints
Clinical note: The outcome in the source study was severe CP-AKI, defined as at least a twofold increase in serum creatinine or receipt of kidney replacement therapy within 14 days. This calculator supports, but does not replace, oncology and nephrology assessment, hydration protocols, medication review, serial renal monitoring, or individualized treatment decisions.

Method and limitations

This page implements the published simplified point score. The full 10-variable primary model uses nonlinear restricted cubic splines and is not reproduced here without its complete coefficient set. In the simplified score, serum creatinine and platelet count do not contribute points, while current or former smoking history is included.

Intended for qualified health professionals. Confirm units, laboratory timing, treatment context, local cisplatin protocols, and patient eligibility before use. Do not use this result as the sole reason to give, withhold, or alter cisplatin.

References

  1. Gupta S, et al. Derivation and validation of a prediction model for cisplatin-associated acute kidney injury. BMJ. 2024;385:e077169. View source article
  2. MDCalc. Cisplatin-Associated Acute Kidney Injury (CP-AKI) Risk Calculator. View clinical reference page

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