The MELD score estimates the 3-month survival probability for patients with end-stage liver disease, helping clinicians make critical decisions about treatment and transplantation.
MELD Score Calculator
Mayo End-Stage Liver Disease Prognostic Tool
What is the MELD Score?
The Model for End-Stage Liver Disease (MELD) score is a widely used prognostic scoring system for patients with chronic liver disease. Originally developed to predict mortality risk in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) procedures, it is now primarily used to prioritize patients for liver transplantation.
The MELD score estimates the 3-month survival probability for patients with end-stage liver disease, helping clinicians make critical decisions about treatment and transplantation.
Clinical Significance
The MELD score has revolutionized liver transplantation by creating an objective, data-driven system for organ allocation. It replaced the previous system that relied heavily on waiting time, helping ensure that the sickest patients receive transplants first.
Calculation Parameters
The MELD score is calculated using three laboratory values:
| Parameter | Significance |
|---|---|
| Serum Bilirubin | Measures liver’s ability to process bile; elevated levels indicate impaired liver function |
| International Normalized Ratio (INR) | Measures blood clotting ability; elevated values indicate impaired synthetic function |
| Serum Creatinine | Measures kidney function; elevated levels may indicate hepatorenal syndrome |
MELD Score Formula
Where “ln” represents the natural logarithm. The score is rounded to the nearest whole number, with a minimum value of 6 and maximum of 40.
Special Considerations
For patients on dialysis twice within the past week, the creatinine value is automatically set to 4.0 mg/dL. Additionally, there are exceptions for certain conditions (like hepatocellular carcinoma) that may increase a patient’s MELD score to reflect their actual transplant urgency.
MELD Score Calculator
Enter the patient’s laboratory values to calculate the MELD score and assess 3-month survival probability.
Score Interpretation
MELD scores are categorized into risk levels with associated 3-month mortality estimates:
Transplant Prioritization
In the United States, the United Network for Organ Sharing (UNOS) uses the MELD score to prioritize patients for liver transplantation:
- MELD ≥ 15: Generally considered for transplant listing
- MELD ≥ 25: High priority for transplantation
- MELD ≥ 35: Highest priority for transplantation
Note: This calculator provides an estimate based on standard MELD calculation. Actual transplant prioritization may include additional factors and exceptions. Always consult with a hepatology specialist for clinical decisions.
