Tobramycin Dosing Calculator
Extended-interval (Hartford-style) and conventional options for adults.References (peer-reviewed + practice standards)
- Hartford once-daily (7 mg/kg) and interval cut-offs; foundational clinical implementation and nomogram lineage. Antimicrob Agents Chemother, 1995 (Nicolau et al.). PMC+1
- Institutional dosing guides reflecting Hartford practice (explicitly state gentamicin/tobramycin 7 mg/kg once-daily; CF often 10 mg/kg; and provide q24h/q36h/q48h intervals). Stanford Health Care Aminoglycoside Dosing Guide; UCSF IDMP Tobramycin page. Stanford Medicine+1
- Extended-interval aminoglycosides in obesity: supports AdjBW with 0.4 factor for gentamicin/tobramycin; morbid-obesity cohort dosed 5–7 mg/kg q24 h using 0.4 correction. ISRN Pharmacol, 2013 (Ross et al.). AAC 2024 dosing in obesity review. PMC+2Wiley Online Library+2
- Aminoglycoside PK/PD & conventional dosing ranges (e.g., 1–2 mg/kg divided, if EIAD unsuitable). Pharmacotherapy/PK review. PMC
- Monitoring (draw a 6–14 h level after the first dose) for extended-interval regimens: practice reviews and protocols. siumed.edu
- Creatinine clearance estimation: original Cockcroft–Gault paper (1976). drugtnt.com
- Ideal body weight: Devine IBW equation and historical commentary (used widely in aminoglycoside dosing). ResearchGate+1
Use this calculator for educational purpose only. It is not a replacement of a health professional’s opinion.
