Gentamicin Dosing Calculator
Extended-interval (Hartford-style) initial dose suggestion for adults.References (peer-reviewed & practice standards)
- Nicolau DP et al. Experience with a once-daily aminoglycoside program — foundational Hartford 7 mg/kg ODA approach and post-dose nomogram monitoring. Antimicrob Agents Chemother. 1995. physiologie.envt.fr
- Chuck SK et al. National survey of extended-interval aminoglycoside dosing — practice trends supporting higher mg/kg once-daily dosing. Clin Infect Dis. 2000. OUP Academic
- Ross AL et al. Extended-interval aminoglycosides in the morbidly obese — validates 0.4 adjusted-weight correction. ISRN Pharmacol. 2013. PMC+1
- Smit C et al. Dose recommendations for gentamicin in the real-world obese — interval extension with impaired kidney function. J Antimicrob Chemother. 2020. OUP Academic
- Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine — standard CrCl estimator used for renally cleared drugs. Nephron. 1976. PubMed+1
- Devine BJ. Origin of the “ideal body weight” equation — IBW used for aminoglycoside dosing. (Historical overview & original formula). Ann Pharmacother commentary and later reviews. ResearchGate+2OUP Academic+2
- For initial EIAD interval cut-offs by CrCl and trough targets, see contemporary institutional protocols reflecting Hartford practice (use local policy): Stanford Health Care Aminoglycoside Dosing Guide (≥60 → q24h; 40–59 → q36h; 30–39 → q48h). 2021. Stanford Medicine
- Recent comprehensive review of antimicrobial dosing in obesity (Aminoglycosides: use AdjBW with 0.4 factor). Antimicrobial Agents and Chemotherapy. 2024. journals.asm.org
Use this calculator for educational purpose only. It is not a replacement of a health practitioner’s opinion.
