Bonacini Cirrhosis Discriminant Score (CDS)
Inputs: Platelets, AST, ALT, INR. Output: CDS score (0–11).
CDS Score: — / 11
AST/ALT ratio: —
Component points — Platelets: —,
AST/ALT: —,
INR: —
Enter values and click Calculate.
The Bonacini Cirrhosis Discriminant Score (CDS) (often just called the Bonacini score) is a simple, non-invasive blood-test–based scoring system used to estimate the likelihood of advanced liver fibrosis/cirrhosis, originally studied in people with chronic hepatitis C.
It adds up points from 3 routine lab components (total range 0–11):
- Platelet count (0–6 points)
- AST/ALT ratio (0–3 points)
- Coagulation measure—originally prothrombin time, commonly implemented as INR (0–2 points)
How it’s used (in general terms):
- Higher scores suggest a higher likelihood of advanced fibrosis/cirrhosis.
- In the original study, a cutoff around ≥8 had high specificity for advanced fibrosis/cirrhosis (meaning a high score was fairly “convincing”), but sensitivity was modest (so a low score doesn’t rule it out by itself).
