ABSIS Calculator (Autoimmune Bullous Skin Disorder Intensity Score)
Calculates skin (0–150), oral extent (0–11), and oral discomfort (0–45) → total ABSIS (0–206). Includes optional severity interpretation bands used in pemphigus cohorts (17 and 53 cutoffs).
Inputs
1) Skin involvement (max 150)
| Region | Max %BSA | Patient %BSA | Lesion quality (weight) | Region points |
|---|
2) Oral involvement (extent, max 11)
3) Oral discomfort during eating/drinking (max 45)
| Food | Level | Factor | Item score |
|---|
ABSIS (Autoimmune Bullous Skin Disorder Intensity Score) is a clinician-used scoring system designed to objectively quantify severity of autoimmune blistering diseases (originally developed for pemphigus), combining cutaneous extent/lesion activity and mucosal involvement plus a patient-reported oral discomfort component. PubMed+2JAMA Network+2
What ABSIS measures (and how it’s built)
ABSIS totals to a 0–206 range made of 3 parts: JAMA Network+1
- Skin involvement (0–150): estimate % body surface area (BSA) involved using a “rule of nines” style regional breakdown, and multiply each region’s %BSA by a lesion-quality weighting factor (e.g., erosive/exudative vs dry vs re-epithelialized). JAMA Network
- Oral involvement extent (0–11): count involved oral/pharyngeal sites (presence/absence). JAMA Network
- Subjective oral discomfort (0–45): patient-reported pain/bleeding with eating/drinking across foods of increasing “difficulty,” using a factor such as never / sometimes / always. JAMA Network
Interpreting ABSIS
ABSIS is often used to track activity over time (baseline → follow-up). For pemphigus classification in one multicenter study of newly diagnosed patients, proposed cutoffs were 17 and 53 to separate moderate, significant, and extensive forms. These thresholds may not generalize to every autoimmune blistering disease, so use local guidance and clinical context. PubMed
