RTOG/EORTC Toxicity Criteria Calculator
Grade the severity of radiation-related side effects (acute or late) using a simplified RTOG/EORTC-style scale for selected tissues.
Select phase and tissue, then choose the description that best matches the clinical picture. Press “Calculate” to display the RTOG/EORTC-style grade and interpretation.
This tool provides a simplified view based on RTOG/EORTC concepts. Always refer to full RTOG/EORTC or CTCAE tables in trials and documentation where required.
This calculator is designed for use by health professionals only and for educational purposes. It does not replace comprehensive toxicity scales, institutional guidelines, or multidisciplinary review. Management decisions must be based on the full clinical context.
RTOG/EORTC Toxicity Criteria are a set of organ-specific grading scales used to describe how severe side effects are from radiotherapy. They were jointly developed by the Radiation Therapy Oncology Group (RTOG) and the European Organisation for Research and Treatment of Cancer (EORTC) and published in 1995.PubMed+1
The system grades radiation morbidity from 0 to 5 for individual tissues (skin, mucosa, lung, bowel, bladder, spinal cord, etc.) and distinguishes between:
- Acute toxicity (usually ≤ 90 days from the start of radiotherapy).
- Late toxicity (> 90 days after treatment), using the RTOG/EORTC late radiation morbidity scoring schema.Wikibooks+1
For each organ and phase, grade 0 means no toxicity, grades 1–4 represent increasing clinical impact (mild → moderate → severe → life-threatening or disabling), and grade 5 is death directly related to radiation effects.Wikibooks These criteria became a standard language in clinical trials to compare regimens and report side effects consistently, and are still used in some protocols, especially for late effects.SciELO+1
Subsequently, the NCI Common Toxicity Criteria / CTCAE version 2.0 incorporated and expanded RTOG acute criteria into a unified system for all treatment modalities.PubMed+2PubMed+2 Modern trials now mostly use CTCAE v4–5+, but many clinicians continue to reference the RTOG/EORTC tables for specific organs (e.g. bowel, lung, bladder) and for long-term follow-up.
